Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4447966..4448726 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF51_RS21705 Protein ID WP_000533912.1
Coordinates 4448241..4448726 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF51_RS21700 Protein ID WP_000965886.1
Coordinates 4447966..4448253 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS21680 (4443371) 4443371..4444282 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF51_RS21685 (4444292) 4444292..4446361 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF51_RS21690 (4446751) 4446751..4447149 + 399 Protein_4217 IS3 family transposase -
LJF51_RS21695 (4447321) 4447321..4447788 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF51_RS21700 (4447966) 4447966..4448253 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF51_RS21705 (4448241) 4448241..4448726 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF51_RS21710 (4449097) 4449097..4449636 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF51_RS21715 (4449810) 4449810..4450022 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF51_RS21720 (4450310) 4450310..4450600 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF51_RS21725 (4451039) 4451039..4451749 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF51_RS21730 (4451799) 4451799..4452773 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF51_RS21735 (4452992) 4452992..4453654 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221587 WP_000533912.1 NZ_CP085802:4448241-4448726 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221587 NZ_CP117511:c2692285-2691944 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221587 WP_000965886.1 NZ_CP085802:4447966-4448253 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221587 NZ_CP117511:c2692515-2692285 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References