Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3747281..3748062 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF51_RS18495 Protein ID WP_000626100.1
Coordinates 3747281..3747772 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF51_RS18500 Protein ID WP_001110452.1
Coordinates 3747769..3748062 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS18460 (3742741) 3742741..3743088 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF51_RS18465 (3743064) 3743064..3744767 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF51_RS18470 (3744804) 3744804..3745379 + 576 WP_001188509.1 transcriptional regulator -
LJF51_RS18480 (3745650) 3745650..3745724 - 75 Protein_3603 helix-turn-helix domain-containing protein -
LJF51_RS18485 (3746104) 3746104..3746181 + 78 Protein_3604 porin family protein -
LJF51_RS18490 (3746281) 3746281..3747033 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF51_RS18495 (3747281) 3747281..3747772 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF51_RS18500 (3747769) 3747769..3748062 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF51_RS18505 (3748379) 3748379..3748600 + 222 WP_001576552.1 hypothetical protein -
LJF51_RS18510 (3748866) 3748866..3749741 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF51_RS18515 (3749738) 3749738..3750025 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF51_RS18520 (3750018) 3750018..3750326 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF51_RS18525 (3750325) 3750325..3750573 + 249 Protein_3612 Ig-like domain-containing protein -
LJF51_RS18530 (3750685) 3750685..3750816 + 132 Protein_3613 hypothetical protein -
LJF51_RS18535 (3751110) 3751110..3752015 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221584 WP_000626100.1 NZ_CP085802:c3747772-3747281 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221584 NZ_CP117511:395931-396239 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221584 WP_001110452.1 NZ_CP085802:c3748062-3747769 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221584 NZ_CP117511:395687-395929 [Enterococcus faecalis]
ATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAATTATGTTTTGAATCATGAACTAGATACTAA
AAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCACAAGAAGTTGATTTATTTCAACAACCATTTG
AAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCAAAACAAATTTTGACAAAAGAGAAAGTGGCT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References