Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2979472..2980092 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF51_RS14835 Protein ID WP_001280991.1
Coordinates 2979874..2980092 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF51_RS14830 Protein ID WP_000344807.1
Coordinates 2979472..2979846 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS14820 (2974611) 2974611..2975804 + 1194 WP_227784346.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF51_RS14825 (2975827) 2975827..2978976 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF51_RS14830 (2979472) 2979472..2979846 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF51_RS14835 (2979874) 2979874..2980092 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF51_RS14840 (2980271) 2980271..2980822 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF51_RS14845 (2980940) 2980940..2981410 + 471 WP_000136183.1 YlaC family protein -
LJF51_RS14850 (2981466) 2981466..2981606 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF51_RS14855 (2981612) 2981612..2981872 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF51_RS14860 (2982097) 2982097..2983647 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF51_RS14870 (2983878) 2983878..2984267 + 390 WP_000961287.1 MGMT family protein -
LJF51_RS14875 (2984300) 2984300..2984869 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221577 WP_001280991.1 NZ_CP085802:2979874-2980092 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221577 NZ_CP117508:c2647381-2647280 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221577 WP_000344807.1 NZ_CP085802:2979472-2979846 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221577 NZ_CP117508:2647156-2647335 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References