Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 359151..359811 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF51_RS01770 Protein ID WP_000244756.1
Coordinates 359398..359811 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF51_RS01765 Protein ID WP_000351186.1
Coordinates 359151..359417 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS01745 (355080) 355080..356513 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJF51_RS01750 (356671) 356671..356982 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF51_RS01755 (357146) 357146..357805 + 660 WP_000250289.1 hemolysin III family protein -
LJF51_RS01760 (357921) 357921..358901 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF51_RS01765 (359151) 359151..359417 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF51_RS01770 (359398) 359398..359811 + 414 WP_000244756.1 protein YgfX Toxin
LJF51_RS01775 (359864) 359864..360385 - 522 WP_001055885.1 flavodoxin FldB -
LJF51_RS01780 (360498) 360498..361394 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF51_RS01785 (361418) 361418..362131 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF51_RS01790 (362137) 362137..363870 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221564 WP_000244756.1 NZ_CP085802:359398-359811 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221564 NZ_CP117503:504361-504477 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221564 WP_000351186.1 NZ_CP085802:359151-359417 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221564 NZ_CP117503:c504593-504388 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References