Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4448105..4448865 Replicon chromosome
Accession NZ_CP085801
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF52_RS21700 Protein ID WP_000533912.1
Coordinates 4448380..4448865 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF52_RS21695 Protein ID WP_000965886.1
Coordinates 4448105..4448392 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF52_RS21675 (4443510) 4443510..4444421 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF52_RS21680 (4444431) 4444431..4446500 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF52_RS21685 (4446890) 4446890..4447288 + 399 Protein_4217 IS3 family transposase -
LJF52_RS21690 (4447460) 4447460..4447927 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF52_RS21695 (4448105) 4448105..4448392 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF52_RS21700 (4448380) 4448380..4448865 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF52_RS21705 (4449236) 4449236..4449775 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF52_RS21710 (4449949) 4449949..4450161 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF52_RS21715 (4450449) 4450449..4450739 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF52_RS21720 (4451178) 4451178..4451888 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF52_RS21725 (4451938) 4451938..4452912 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF52_RS21730 (4453131) 4453131..4453793 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221561 WP_000533912.1 NZ_CP085801:4448380-4448865 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221561 NZ_CP117484:c31559-31143 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCTATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221561 WP_000965886.1 NZ_CP085801:4448105-4448392 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221561 NZ_CP117484:c31786-31556 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References