Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3747420..3748201 Replicon chromosome
Accession NZ_CP085801
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF52_RS18490 Protein ID WP_000626100.1
Coordinates 3747420..3747911 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF52_RS18495 Protein ID WP_001110452.1
Coordinates 3747908..3748201 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF52_RS18455 (3742880) 3742880..3743227 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF52_RS18460 (3743203) 3743203..3744906 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF52_RS18465 (3744943) 3744943..3745518 + 576 WP_001188509.1 transcriptional regulator -
LJF52_RS18475 (3745789) 3745789..3745863 - 75 Protein_3603 helix-turn-helix domain-containing protein -
LJF52_RS18480 (3746243) 3746243..3746320 + 78 Protein_3604 porin family protein -
LJF52_RS18485 (3746420) 3746420..3747172 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF52_RS18490 (3747420) 3747420..3747911 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF52_RS18495 (3747908) 3747908..3748201 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF52_RS18500 (3748518) 3748518..3748739 + 222 WP_001576552.1 hypothetical protein -
LJF52_RS18505 (3749005) 3749005..3749880 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF52_RS18510 (3749877) 3749877..3750164 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF52_RS18515 (3750157) 3750157..3750465 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF52_RS18520 (3750464) 3750464..3750712 + 249 Protein_3612 Ig-like domain-containing protein -
LJF52_RS18525 (3750824) 3750824..3750955 + 132 Protein_3613 hypothetical protein -
LJF52_RS18530 (3751249) 3751249..3752154 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221558 WP_000626100.1 NZ_CP085801:c3747911-3747420 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221558 NZ_CP117481:c5198671-5198288 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGCTGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221558 WP_001110452.1 NZ_CP085801:c3748201-3747908 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221558 NZ_CP117481:c5198913-5198671 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References