Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3599399..3599949 Replicon chromosome
Accession NZ_CP085801
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF52_RS17695 Protein ID WP_001199743.1
Coordinates 3599399..3599707 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF52_RS17700 Protein ID WP_001118105.1
Coordinates 3599710..3599949 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF52_RS17675 (3595973) 3595973..3596713 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF52_RS17680 (3596835) 3596835..3597365 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF52_RS17685 (3597688) 3597688..3598821 + 1134 Protein_3452 IS3 family transposase -
LJF52_RS17690 (3598853) 3598853..3598993 - 141 Protein_3453 Arm DNA-binding domain-containing protein -
LJF52_RS17695 (3599399) 3599399..3599707 - 309 WP_001199743.1 CcdB family protein Toxin
LJF52_RS17700 (3599710) 3599710..3599949 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF52_RS17705 (3600058) 3600058..3600306 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF52_RS17710 (3600383) 3600383..3600928 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF52_RS17725 (3601685) 3601685..3602704 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF52_RS17730 (3602732) 3602732..3603262 - 531 WP_000896758.1 gluconokinase -
LJF52_RS17735 (3603479) 3603479..3604510 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3597780..3600883 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221556 WP_001199743.1 NZ_CP085801:c3599707-3599399 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221556 NZ_CP117481:c4703878-4703594 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221556 WP_001118105.1 NZ_CP085801:c3599949-3599710 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221556 NZ_CP117481:c4704110-4703868 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References