Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2979611..2980231 Replicon chromosome
Accession NZ_CP085801
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF52_RS14835 Protein ID WP_001280991.1
Coordinates 2980013..2980231 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF52_RS14830 Protein ID WP_000344807.1
Coordinates 2979611..2979985 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF52_RS14820 (2974750) 2974750..2975943 + 1194 WP_227784346.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF52_RS14825 (2975966) 2975966..2979115 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF52_RS14830 (2979611) 2979611..2979985 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF52_RS14835 (2980013) 2980013..2980231 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF52_RS14840 (2980410) 2980410..2980961 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF52_RS14845 (2981079) 2981079..2981549 + 471 WP_000136183.1 YlaC family protein -
LJF52_RS14850 (2981605) 2981605..2981745 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF52_RS14855 (2981751) 2981751..2982011 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF52_RS14860 (2982236) 2982236..2983786 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF52_RS14870 (2984017) 2984017..2984406 + 390 WP_000961287.1 MGMT family protein -
LJF52_RS14875 (2984439) 2984439..2985008 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221551 WP_001280991.1 NZ_CP085801:2980013-2980231 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221551 NZ_CP117481:839545-839955 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221551 WP_000344807.1 NZ_CP085801:2979611-2979985 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221551 NZ_CP117481:839298-839564 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References