Detailed information of TA system TA022155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385588..1386276
• Replicon: chromosome
• Accession: NC_009525
• Organism: Mycobacterium tuberculosis H37Ra

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: MRA_RS06595
• Protein ID: WP_003406304.1
• Coordinates: 1385845..1386276 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: MRA_RS06590
• Protein ID: WP_003406302.1
• Coordinates: 1385588..1385848 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRA_RS06570	1381165..1381989	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
MRA_RS06575	1381994..1383175	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
MRA_RS06580	1383252..1384352	-	1101	WP_003916789.1	magnesium/cobalt transporter CorA	-
MRA_RS06585	1384523..1385512	+	990	WP_003406301.1	malate dehydrogenase	-
MRA_RS06590	1385588..1385848	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
MRA_RS06595	1385845..1386276	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
MRA_RS06600	1386299..1387987	-	1689	WP_003910308.1	PE family protein	-
MRA_RS06605	1388167..1389027	+	861	WP_003900301.1	hypothetical protein	-
MRA_RS06610	1389108..1389938	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
MRA_RS06615	1389995..1390288	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
MRA_RS06620	1390285..1390554	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T22155 WP_003406304.1 NC_009525:1385845-1386276 [Mycobacterium tuberculosis H37Ra]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T22155 NC_009525:1385845-1386276 [Mycobacterium tuberculosis H37Ra]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT22155 WP_003406302.1 NC_009525:1385588-1385848 [Mycobacterium tuberculosis H37Ra]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT22155 NC_009525:1385588-1385848 [Mycobacterium tuberculosis H37Ra]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6