Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 359267..359927 Replicon chromosome
Accession NZ_CP085801
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF52_RS01770 Protein ID WP_000244756.1
Coordinates 359514..359927 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF52_RS01765 Protein ID WP_000351186.1
Coordinates 359267..359533 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF52_RS01745 (355196) 355196..356629 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJF52_RS01750 (356787) 356787..357098 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF52_RS01755 (357262) 357262..357921 + 660 WP_000250289.1 hemolysin III family protein -
LJF52_RS01760 (358037) 358037..359017 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF52_RS01765 (359267) 359267..359533 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF52_RS01770 (359514) 359514..359927 + 414 WP_000244756.1 protein YgfX Toxin
LJF52_RS01775 (359980) 359980..360501 - 522 WP_001055885.1 flavodoxin FldB -
LJF52_RS01780 (360614) 360614..361510 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF52_RS01785 (361534) 361534..362247 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF52_RS01790 (362253) 362253..363986 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221538 WP_000244756.1 NZ_CP085801:359514-359927 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221538 NZ_CP117470:4617223-4618545 [Aeromonas hydrophila]
ATGGCCAGCCTGGCGGTATACATGAACGGATACCGGGTGGGTTCTTTTATCAAGAGAACCAGCGGTGCCCACCAATTTCA
GTACGATGAGTCTTGGGTGAAGCTGCCAGGTAGTCGCCCCATCTCGCTCTCAATGCCGTTACGCCAGCAGTGCTATCGGG
GCGATGAGGCTTATAACTTCTTCGATAACCTGTTGCCGGATAGCCAGGAAGTGAGAAACCGGGTGGTGGCGCGCTATCAA
GCTGACTCTACCCAGCCCTTTGACTTACTCAGTTACATTGGTTCGGACAGCGTGGGTGCATTGCAACTGGTGGCTCATGG
CGGCCCAGTGCCAGACGTCAGAAGTATCGAGTACAAACCTCTCTCTGACGTTGAGCTGGAAAGGATCCTGACTGGTTACC
AGTCGGGGATCCCTCTTGGTATGATCAGGGAAGAGGAGGACTTCCGGATATCGATCGCAGGTGCCCAAGAAAAGACGGCA
CTCCTTTATCTCGATGGTCGCTGGTGTTTGCCAATCGCGGATACCCCGACCACCCACATTATCAAGTTGCCCATTGGCAA
AATTGAGAGCCACTCCTATTCGATAGATCTCACCCAAAGCGTGGAGAACGAGTATCTCTGTACCCTGATCGCCAAAGAGT
TTGGTCTTCCCGTCCCCCATTGTTTCATCATGCAAGTGAATAAGGTCAAGGCGCTGGCAGTGGAACGCTTCGATAGGCGC
TACGCCACGGATCGCAGCTGGATAATGCGTCTGCCCCAAGAGGACTTCTGCCAAGTGCTGAATGTGCCGTCAGCACGGAA
GTACGAGAGCCATGGTGGGCCAGGTATTGTTGGCATCATGGCGACTCTGCTGGGGTCTACCACGCCGGAGCAGGATCGTT
ACCTGTTCATGAAGTCTCAAGTGCTGTTCTGGCTGCTGGCCGCCACCGACGGCCATGCCAAGAATTTTTCGGTGTTCATC
GAGTCAGAGGGGCGCTTCCGGCTGACACCGTTTTACGACATCCTCTCCATGTATCCCGTGTTCGGCGGCAGAGGGTTGCA
TCCTCGCGATGCCAAGCTGGCCATGGGACTTACCGCAACCAAAGGTAAGAAATACACCATAGAACAGATCTTCCCCCGCC
ATTTCTATCAGACAGCCAAGGCGGTTGGTTTTGAGCAGGCACAGATGGCACAGATCCTGAACGAGTTTGCAGAGAATACA
GATCGTGTCATTGAGCTGGTTCGCCAGCAGTTACCTGCTCATTTTCCTGCTCAAGTTGCCGATTCGATTCTGAATGGGTT
TCAGGCTCGAGCAATGCGTGTGGCTAGGTCTAGAGATGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221538 WP_000351186.1 NZ_CP085801:359267-359533 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221538 NZ_CP117470:4616969-4617223 [Aeromonas hydrophila]
ATGAAAATTACTAGTGCCAAGCAACTCAGTGCCTATCTCAGAGATGCCAGGCTTTTGCAAAAGCTGTCTCAAGGTAAGGT
GGCCGACAAAGTTGGGATTCGGCAGGACACTGTCTCCAGCTTTGAGCTTAATCCCGAGTCAACCAAGCTGGATACCTTGT
TCAAGATCCTCGCCGCGCTGGAGTTATCCCTCGATATCAAACCCCGTACCGACCCACCGGATAGCCCTTCATCAGGCTGG
AAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References