Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3746859..3747619 Replicon chromosome
Accession NZ_CP085800
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Taillow

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF53_RS18345 Protein ID WP_000533912.1
Coordinates 3747134..3747619 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF53_RS18340 Protein ID WP_000965886.1
Coordinates 3746859..3747146 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF53_RS18320 (3742264) 3742264..3743175 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF53_RS18325 (3743185) 3743185..3745254 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF53_RS18330 (3745644) 3745644..3746042 + 399 Protein_3568 IS3 family transposase -
LJF53_RS18335 (3746214) 3746214..3746681 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF53_RS18340 (3746859) 3746859..3747146 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF53_RS18345 (3747134) 3747134..3747619 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF53_RS18350 (3747990) 3747990..3748529 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF53_RS18355 (3748703) 3748703..3748915 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF53_RS18360 (3749203) 3749203..3749493 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF53_RS18365 (3749932) 3749932..3750642 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF53_RS18370 (3750692) 3750692..3751666 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF53_RS18375 (3751885) 3751885..3752547 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221532 WP_000533912.1 NZ_CP085800:3747134-3747619 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221532 NZ_CP117411:2466742-2467062 [Sphingomonas naphthae]
GTGAGGCGCGGCGACATCGTCACGATCGCGACGCCCGGCGACTTCGGCAAGCCACGGCCGGCGCTCATCATCCAGTCGGA
TCAGTTCGAGACCGGCACGATCACCGTTCTGCTCGTTACAAGCACCCTGCTGGACGCGCCGCTGTTACGGCCGAGCATTC
AGCCGTCGCCCGAGAATGGACTGCGAAAGCCCTCTCAGGTGATGATCGACAAGCCCATGAGCATCAGACGCGATCGGATC
GGCGATGTCTTCGGGCGGCTCGATGCGGAAACGATGCTCGCCGTCACCCGCGCGCTGGCGGTGTTTCTGGGCATAGCCTG
A

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221532 WP_000965886.1 NZ_CP085800:3746859-3747146 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221532 NZ_CP117411:2466527-2466745 [Sphingomonas naphthae]
ATGGCCATGCCGATCAGTCAGCGGGTTCAAAAGCGGCGCGATGCGATGCGCGCGGCGGGCCTGCGCCCTATTCAGATATG
GGTGCCGGATACCCGGCGCGAAGGCTTCACCGAGGAATGCCGGCGGCAGGCGCGAATGGTCGCCATGGCCGATGCGGCGG
ATCGCGACCTGACCGACTTTCTCGATGAGGCGCTGCTCGATCTCGAGCGGGACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References