Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3013949..3014730 Replicon chromosome
Accession NZ_CP085800
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Taillow

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF53_RS14890 Protein ID WP_000626100.1
Coordinates 3013949..3014440 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF53_RS14895 Protein ID WP_001110452.1
Coordinates 3014437..3014730 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF53_RS14855 (3009409) 3009409..3009756 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF53_RS14860 (3009732) 3009732..3011435 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF53_RS14865 (3011472) 3011472..3012047 + 576 WP_001188509.1 transcriptional regulator -
LJF53_RS14875 (3012318) 3012318..3012392 - 75 Protein_2905 helix-turn-helix domain-containing protein -
LJF53_RS14880 (3012772) 3012772..3012849 + 78 Protein_2906 porin family protein -
LJF53_RS14885 (3012949) 3012949..3013701 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF53_RS14890 (3013949) 3013949..3014440 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF53_RS14895 (3014437) 3014437..3014730 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF53_RS14900 (3015047) 3015047..3015268 + 222 WP_001576552.1 hypothetical protein -
LJF53_RS14905 (3015534) 3015534..3016409 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF53_RS14910 (3016406) 3016406..3016693 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF53_RS14915 (3016686) 3016686..3016994 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF53_RS14920 (3016993) 3016993..3017241 + 249 Protein_2914 Ig-like domain-containing protein -
LJF53_RS14925 (3017353) 3017353..3017484 + 132 Protein_2915 hypothetical protein -
LJF53_RS14930 (3017778) 3017778..3018683 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221529 WP_000626100.1 NZ_CP085800:c3014440-3013949 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221529 NZ_CP117404:c4654655-4654344 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TGTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221529 WP_001110452.1 NZ_CP085800:c3014730-3014437 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221529 NZ_CP117404:c4654343-4654053 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References