Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2245993..2246613 Replicon chromosome
Accession NZ_CP085800
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Taillow

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF53_RS11235 Protein ID WP_001280991.1
Coordinates 2246395..2246613 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF53_RS11230 Protein ID WP_000344807.1
Coordinates 2245993..2246367 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF53_RS11220 (2241132) 2241132..2242325 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF53_RS11225 (2242348) 2242348..2245497 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF53_RS11230 (2245993) 2245993..2246367 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF53_RS11235 (2246395) 2246395..2246613 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF53_RS11240 (2246792) 2246792..2247343 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF53_RS11245 (2247461) 2247461..2247931 + 471 WP_000136183.1 YlaC family protein -
LJF53_RS11250 (2247987) 2247987..2248127 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF53_RS11255 (2248133) 2248133..2248393 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF53_RS11260 (2248618) 2248618..2250168 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF53_RS11270 (2250399) 2250399..2250788 + 390 WP_000961287.1 MGMT family protein -
LJF53_RS11275 (2250821) 2250821..2251390 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221522 WP_001280991.1 NZ_CP085800:2246395-2246613 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221522 NZ_CP117404:3478461-3478679 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221522 WP_000344807.1 NZ_CP085800:2245993-2246367 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221522 NZ_CP117404:3478059-3478433 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References