Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4371637..4372297 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF54_RS21395 Protein ID WP_000244756.1
Coordinates 4371884..4372297 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF54_RS21390 Protein ID WP_000351186.1
Coordinates 4371637..4371903 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF54_RS21370 (4367566) 4367566..4368999 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJF54_RS21375 (4369157) 4369157..4369468 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF54_RS21380 (4369632) 4369632..4370291 + 660 WP_000250289.1 hemolysin III family protein -
LJF54_RS21385 (4370407) 4370407..4371387 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF54_RS21390 (4371637) 4371637..4371903 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF54_RS21395 (4371884) 4371884..4372297 + 414 WP_000244756.1 protein YgfX Toxin
LJF54_RS21400 (4372350) 4372350..4372871 - 522 WP_001055885.1 flavodoxin FldB -
LJF54_RS21405 (4372984) 4372984..4373880 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF54_RS21410 (4373904) 4373904..4374617 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF54_RS21415 (4374623) 4374623..4376356 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221509 WP_000244756.1 NZ_CP085799:4371884-4372297 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221509 NZ_CP117402:c3949445-3949137 [Salmonella enterica subsp. enterica serovar Give]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221509 WP_000351186.1 NZ_CP085799:4371637-4371903 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221509 NZ_CP117402:c3949687-3949448 [Salmonella enterica subsp. enterica serovar Give]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTGCTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References