221506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3746803..3747563 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF54_RS18350 Protein ID WP_000533912.1
Coordinates 3747078..3747563 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF54_RS18345 Protein ID WP_000965886.1
Coordinates 3746803..3747090 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF54_RS18325 (3742208) 3742208..3743119 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF54_RS18330 (3743129) 3743129..3745198 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF54_RS18335 (3745588) 3745588..3745986 + 399 Protein_3569 IS3 family transposase -
LJF54_RS18340 (3746158) 3746158..3746625 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF54_RS18345 (3746803) 3746803..3747090 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF54_RS18350 (3747078) 3747078..3747563 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF54_RS18355 (3747934) 3747934..3748473 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF54_RS18360 (3748647) 3748647..3748859 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF54_RS18365 (3749147) 3749147..3749437 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF54_RS18370 (3749876) 3749876..3750586 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF54_RS18375 (3750636) 3750636..3751610 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF54_RS18380 (3751829) 3751829..3752491 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221506 WP_000533912.1 NZ_CP085799:3747078-3747563 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221506 NZ_CP117402:1961070-1961173 [Salmonella enterica subsp. enterica serovar Give]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221506 WP_000965886.1 NZ_CP085799:3746803-3747090 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221506 NZ_CP117402:c1961175-1961032 [Salmonella enterica subsp. enterica serovar Give]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References