Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3013850..3014631 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF54_RS14895 Protein ID WP_000626100.1
Coordinates 3013850..3014341 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF54_RS14900 Protein ID WP_001110452.1
Coordinates 3014338..3014631 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF54_RS14860 (3009310) 3009310..3009657 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF54_RS14865 (3009633) 3009633..3011336 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF54_RS14870 (3011373) 3011373..3011948 + 576 WP_001188509.1 transcriptional regulator -
LJF54_RS14880 (3012219) 3012219..3012293 - 75 Protein_2906 helix-turn-helix domain-containing protein -
LJF54_RS14885 (3012673) 3012673..3012750 + 78 Protein_2907 porin family protein -
LJF54_RS14890 (3012850) 3012850..3013602 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF54_RS14895 (3013850) 3013850..3014341 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF54_RS14900 (3014338) 3014338..3014631 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF54_RS14905 (3014948) 3014948..3015169 + 222 WP_001576552.1 hypothetical protein -
LJF54_RS14910 (3015435) 3015435..3016310 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF54_RS14915 (3016307) 3016307..3016594 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF54_RS14920 (3016587) 3016587..3016895 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF54_RS14925 (3016894) 3016894..3017142 + 249 Protein_2915 Ig-like domain-containing protein -
LJF54_RS14930 (3017254) 3017254..3017385 + 132 Protein_2916 hypothetical protein -
LJF54_RS14935 (3017679) 3017679..3018584 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221503 WP_000626100.1 NZ_CP085799:c3014341-3013850 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221503 NZ_CP117401:c14266-13916 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221503 WP_001110452.1 NZ_CP085799:c3014631-3014338 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221503 NZ_CP117401:c13911-13609 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References