Detailed information of TA system TA221502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2906954..2907470
• Replicon: chromosome
• Accession: NZ_CP085799
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B5R9I9
• Locus tag: LJF54_RS14320
• Protein ID: WP_000220582.1
• Coordinates: 2906954..2907238 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: LJF54_RS14325
• Protein ID: WP_000212724.1
• Coordinates: 2907228..2907470 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF54_RS14305 (2902165)	2902165..2903817	+	1653	WP_000155048.1	alpha,alpha-phosphotrehalase	-
LJF54_RS14310 (2904226)	2904226..2906364	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
LJF54_RS14315 (2906486)	2906486..2906950	+	465	WP_001268859.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LJF54_RS14320 (2906954)	2906954..2907238	-	285	WP_000220582.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJF54_RS14325 (2907228)	2907228..2907470	-	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LJF54_RS14330 (2907548)	2907548..2909461	-	1914	WP_001212142.1	BglG family transcription antiterminator	-
LJF54_RS14335 (2909478)	2909478..2910218	-	741	WP_000779259.1	KDGP aldolase family protein	-
LJF54_RS14340 (2910215)	2910215..2911333	-	1119	WP_001139169.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
LJF54_RS14345 (2911317)	2911317..2912450	-	1134	WP_000459957.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10912.66 Da
• Isoelectric Point: 9.6743

>T221502 WP_000220582.1 NZ_CP085799:c2907238-2906954 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T221502 NZ_CP117400:4718561-4718872 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT221502 WP_000212724.1 NZ_CP085799:c2907470-2907228 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT221502 NZ_CP117400:4718869-4719315 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: A0A656ILJ8

Antitoxin

• AlphaFold DB: A0A5H5JRI5