Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2246023..2246643 Replicon chromosome
Accession NZ_CP085799
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF54_RS11240 Protein ID WP_001280991.1
Coordinates 2246425..2246643 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF54_RS11235 Protein ID WP_000344807.1
Coordinates 2246023..2246397 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF54_RS11225 (2241162) 2241162..2242355 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF54_RS11230 (2242378) 2242378..2245527 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF54_RS11235 (2246023) 2246023..2246397 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF54_RS11240 (2246425) 2246425..2246643 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF54_RS11245 (2246822) 2246822..2247373 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF54_RS11250 (2247491) 2247491..2247961 + 471 WP_000136183.1 YlaC family protein -
LJF54_RS11255 (2248017) 2248017..2248157 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF54_RS11260 (2248163) 2248163..2248423 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF54_RS11265 (2248648) 2248648..2250198 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF54_RS11275 (2250429) 2250429..2250818 + 390 WP_000961287.1 MGMT family protein -
LJF54_RS11280 (2250851) 2250851..2251420 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221496 WP_001280991.1 NZ_CP085799:2246425-2246643 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221496 NZ_CP117400:3532436-3532654 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221496 WP_000344807.1 NZ_CP085799:2246023-2246397 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221496 NZ_CP117400:3532034-3532408 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References