Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3749131..3749912 Replicon chromosome
Accession NZ_CP085798
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF55_RS18480 Protein ID WP_000626100.1
Coordinates 3749131..3749622 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF55_RS18485 Protein ID WP_001110452.1
Coordinates 3749619..3749912 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF55_RS18445 (3744591) 3744591..3744938 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF55_RS18450 (3744914) 3744914..3746617 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF55_RS18455 (3746654) 3746654..3747229 + 576 WP_001188509.1 transcriptional regulator -
LJF55_RS18465 (3747500) 3747500..3747574 - 75 Protein_3601 helix-turn-helix domain-containing protein -
LJF55_RS18470 (3747954) 3747954..3748031 + 78 Protein_3602 porin family protein -
LJF55_RS18475 (3748131) 3748131..3748883 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF55_RS18480 (3749131) 3749131..3749622 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF55_RS18485 (3749619) 3749619..3749912 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF55_RS18490 (3750229) 3750229..3750450 + 222 WP_001576552.1 hypothetical protein -
LJF55_RS18495 (3750716) 3750716..3751591 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF55_RS18500 (3751588) 3751588..3751875 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF55_RS18505 (3751868) 3751868..3752176 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF55_RS18510 (3752175) 3752175..3752423 + 249 Protein_3610 Ig-like domain-containing protein -
LJF55_RS18515 (3752535) 3752535..3752666 + 132 Protein_3611 hypothetical protein -
LJF55_RS18520 (3752960) 3752960..3753865 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221480 WP_000626100.1 NZ_CP085798:c3749622-3749131 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221480 NZ_CP085798:c3749622-3749131 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221480 WP_001110452.1 NZ_CP085798:c3749912-3749619 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221480 NZ_CP085798:c3749912-3749619 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References