Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 559298..560079 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF56_RS02635 Protein ID WP_000626100.1
Coordinates 559298..559789 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF56_RS02640 Protein ID WP_001110452.1
Coordinates 559786..560079 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS02600 (554758) 554758..555105 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF56_RS02605 (555081) 555081..556784 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF56_RS02610 (556821) 556821..557396 + 576 WP_001188509.1 transcriptional regulator -
LJF56_RS02620 (557667) 557667..557741 - 75 Protein_508 helix-turn-helix domain-containing protein -
LJF56_RS02625 (558121) 558121..558198 + 78 Protein_509 porin family protein -
LJF56_RS02630 (558298) 558298..559050 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF56_RS02635 (559298) 559298..559789 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF56_RS02640 (559786) 559786..560079 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF56_RS02645 (560396) 560396..560617 + 222 WP_001576552.1 hypothetical protein -
LJF56_RS02650 (560883) 560883..561758 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF56_RS02655 (561755) 561755..562042 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF56_RS02660 (562035) 562035..562343 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF56_RS02665 (562342) 562342..562590 + 249 Protein_517 Ig-like domain-containing protein -
LJF56_RS02670 (562702) 562702..562833 + 132 Protein_518 hypothetical protein -
LJF56_RS02675 (563127) 563127..564032 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221437 WP_000626100.1 NZ_CP085797:c559789-559298 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221437 NZ_CP117392:c4128189-4127698 [Salmonella enterica subsp. enterica serovar Give]
ATGATCTCCGCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGAGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221437 WP_001110452.1 NZ_CP085797:c560079-559786 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221437 NZ_CP117392:c4128479-4128186 [Salmonella enterica subsp. enterica serovar Give]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCCGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTCGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References