Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 367016..367592 Replicon chromosome
Accession NZ_CP085797
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF56_RS01630 Protein ID WP_001131963.1
Coordinates 367305..367592 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF56_RS01625 Protein ID WP_000063142.1
Coordinates 367016..367318 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF56_RS01610 (363526) 363526..365676 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
LJF56_RS01615 (365771) 365771..365974 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF56_RS01620 (365985) 365985..366941 + 957 WP_000187843.1 GTPase -
LJF56_RS01625 (367016) 367016..367318 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF56_RS01630 (367305) 367305..367592 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF56_RS01635 (368009) 368009..369265 + 1257 Protein_318 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF56_RS01640 (369259) 369259..369438 + 180 Protein_319 DNA methyltransferase -
LJF56_RS01645 (369428) 369428..370732 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221434 WP_001131963.1 NZ_CP085797:c367592-367305 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221434 NZ_CP117392:3321082-3321300 [Salmonella enterica subsp. enterica serovar Give]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221434 WP_000063142.1 NZ_CP085797:c367318-367016 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221434 NZ_CP117392:3320680-3321054 [Salmonella enterica subsp. enterica serovar Give]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References