Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4324490..4325150 Replicon chromosome
Accession NZ_CP085796
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF57_RS20990 Protein ID WP_000244756.1
Coordinates 4324490..4324903 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF57_RS20995 Protein ID WP_000351186.1
Coordinates 4324884..4325150 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF57_RS20970 (4320431) 4320431..4322164 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
LJF57_RS20975 (4322170) 4322170..4322883 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF57_RS20980 (4322907) 4322907..4323803 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF57_RS20985 (4323916) 4323916..4324437 + 522 WP_001055885.1 flavodoxin FldB -
LJF57_RS20990 (4324490) 4324490..4324903 - 414 WP_000244756.1 protein YgfX Toxin
LJF57_RS20995 (4324884) 4324884..4325150 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF57_RS21000 (4325400) 4325400..4326380 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF57_RS21005 (4326496) 4326496..4327155 - 660 WP_000250289.1 hemolysin III family protein -
LJF57_RS21010 (4327319) 4327319..4327630 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF57_RS21015 (4327788) 4327788..4329221 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221433 WP_000244756.1 NZ_CP085796:c4324903-4324490 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221433 NZ_CP117392:2319412-2319696 [Salmonella enterica subsp. enterica serovar Give]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACAACACAGAAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221433 WP_000351186.1 NZ_CP085796:c4325150-4324884 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221433 NZ_CP117392:2319174-2319422 [Salmonella enterica subsp. enterica serovar Give]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References