221414

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1077747..1078263 Replicon chromosome
Accession NZ_CP085796
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF57_RS05080 Protein ID WP_000220582.1
Coordinates 1077979..1078263 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF57_RS05075 Protein ID WP_000212724.1
Coordinates 1077747..1077989 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF57_RS05055 (1072767) 1072767..1073900 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LJF57_RS05060 (1073884) 1073884..1075002 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF57_RS05065 (1074999) 1074999..1075739 + 741 WP_000779259.1 KDGP aldolase family protein -
LJF57_RS05070 (1075756) 1075756..1077669 + 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF57_RS05075 (1077747) 1077747..1077989 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF57_RS05080 (1077979) 1077979..1078263 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF57_RS05085 (1078267) 1078267..1078731 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF57_RS05090 (1078853) 1078853..1080991 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF57_RS05095 (1081400) 1081400..1083052 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221414 WP_000220582.1 NZ_CP085796:1077979-1078263 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221414 NZ_CP117390:188843-189328 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221414 WP_000212724.1 NZ_CP085796:1077747-1077989 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221414 NZ_CP117390:188568-188855 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8


Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References