Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 970586..971367 | Replicon | chromosome |
| Accession | NZ_CP085796 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | LJF57_RS04505 | Protein ID | WP_000626100.1 |
| Coordinates | 970876..971367 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | LJF57_RS04500 | Protein ID | WP_001110452.1 |
| Coordinates | 970586..970879 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF57_RS04465 (966633) | 966633..967538 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| LJF57_RS04470 (967832) | 967832..967963 | - | 132 | Protein_859 | hypothetical protein | - |
| LJF57_RS04475 (968075) | 968075..968323 | - | 249 | Protein_860 | Ig-like domain-containing protein | - |
| LJF57_RS04480 (968322) | 968322..968630 | + | 309 | WP_072095651.1 | ABC transporter ATP-binding protein | - |
| LJF57_RS04485 (968623) | 968623..968910 | - | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| LJF57_RS04490 (968907) | 968907..969782 | - | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| LJF57_RS04495 (970048) | 970048..970269 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| LJF57_RS04500 (970586) | 970586..970879 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| LJF57_RS04505 (970876) | 970876..971367 | + | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| LJF57_RS04510 (971615) | 971615..972367 | - | 753 | WP_000842433.1 | non-specific acid phosphatase | - |
| LJF57_RS04515 (972467) | 972467..972544 | - | 78 | Protein_868 | porin family protein | - |
| LJF57_RS04520 (972924) | 972924..972998 | + | 75 | Protein_869 | helix-turn-helix domain-containing protein | - |
| LJF57_RS04530 (973269) | 973269..973844 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
| LJF57_RS04535 (973881) | 973881..975584 | - | 1704 | WP_000068885.1 | protein-disulfide reductase DsbD | - |
| LJF57_RS04540 (975560) | 975560..975907 | - | 348 | WP_000887832.1 | divalent cation tolerance protein CutA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T221413 WP_000626100.1 NZ_CP085796:970876-971367 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T221413 NZ_CP117389:c14266-13916 [Salmonella enterica subsp. enterica serovar Uganda]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT221413 WP_001110452.1 NZ_CP085796:970586-970879 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT221413 NZ_CP117389:c13911-13609 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I1DGA4 |