Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704554..705197 Replicon chromosome
Accession NC_009525
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag MRA_RS03190 Protein ID WP_003403187.1
Coordinates 704796..705197 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag MRA_RS03185 Protein ID WP_003403184.1
Coordinates 704554..704799 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRA_RS03150 699834..700364 - 531 WP_003917320.1 two component system sensor kinase HK2 -
MRA_RS03155 700348..701109 - 762 WP_003403148.1 two-component system response regulator TcrA -
MRA_RS03160 701166..701477 + 312 WP_003403164.1 hypothetical protein -
MRA_RS03165 701549..702499 + 951 WP_003900184.1 DUF1259 domain-containing protein -
MRA_RS03170 702740..703324 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MRA_RS03175 703326..704036 + 711 Protein_628 transposase -
MRA_RS03180 704039..704509 + 471 WP_003898523.1 hypothetical protein -
MRA_RS03185 704554..704799 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MRA_RS03190 704796..705197 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
MRA_RS22260 705585..705752 - 168 WP_077385191.1 DUF3800 domain-containing protein -
MRA_RS22265 705785..705982 - 198 WP_003403191.1 hypothetical protein -
MRA_RS03205 706062..707219 - 1158 WP_003898524.1 hypothetical protein -
MRA_RS03210 707271..707492 - 222 WP_003898525.1 DUF4926 domain-containing protein -
MRA_RS03215 707634..708239 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T22141 WP_003403187.1 NC_009525:704796-705197 [Mycobacterium tuberculosis H37Ra]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T22141 NC_009525:704796-705197 [Mycobacterium tuberculosis H37Ra]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT22141 WP_003403184.1 NC_009525:704554-704799 [Mycobacterium tuberculosis H37Ra]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT22141 NC_009525:704554-704799 [Mycobacterium tuberculosis H37Ra]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References