Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1819060..1819610 Replicon chromosome
Accession NZ_CP085795
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF59_RS08665 Protein ID WP_001199743.1
Coordinates 1819302..1819610 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF59_RS08660 Protein ID WP_001118105.1
Coordinates 1819060..1819299 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF59_RS08625 (1814499) 1814499..1815530 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF59_RS08630 (1815747) 1815747..1816277 + 531 WP_000896758.1 gluconokinase -
LJF59_RS08635 (1816305) 1816305..1817324 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF59_RS08650 (1818081) 1818081..1818626 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF59_RS08655 (1818703) 1818703..1818951 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF59_RS08660 (1819060) 1819060..1819299 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF59_RS08665 (1819302) 1819302..1819610 + 309 WP_001199743.1 CcdB family protein Toxin
LJF59_RS08670 (1820016) 1820016..1820156 + 141 Protein_1668 Arm DNA-binding domain-containing protein -
LJF59_RS08675 (1820188) 1820188..1821321 - 1134 Protein_1669 IS3 family transposase -
LJF59_RS08680 (1821644) 1821644..1822174 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF59_RS08685 (1822296) 1822296..1823036 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1818126..1821229 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221392 WP_001199743.1 NZ_CP085795:1819302-1819610 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221392 NZ_CP117386:3690210-3690467 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCACCTTAAGGGTGACTGGCTGGAAGAAGCGGGATTTGAGACCGGGCGCGGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221392 WP_001118105.1 NZ_CP085795:1819060-1819299 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221392 NZ_CP117386:c3690385-3690117 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References