221390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1670808..1671589 Replicon chromosome
Accession NZ_CP085795
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF59_RS07870 Protein ID WP_000626100.1
Coordinates 1671098..1671589 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF59_RS07865 Protein ID WP_001110452.1
Coordinates 1670808..1671101 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF59_RS07830 (1666855) 1666855..1667760 + 906 WP_001268200.1 YjiK family protein -
LJF59_RS07835 (1668054) 1668054..1668185 - 132 Protein_1508 hypothetical protein -
LJF59_RS07840 (1668297) 1668297..1668545 - 249 Protein_1509 Ig-like domain-containing protein -
LJF59_RS07845 (1668544) 1668544..1668852 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF59_RS07850 (1668845) 1668845..1669132 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF59_RS07855 (1669129) 1669129..1670004 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF59_RS07860 (1670270) 1670270..1670491 - 222 WP_001576552.1 hypothetical protein -
LJF59_RS07865 (1670808) 1670808..1671101 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF59_RS07870 (1671098) 1671098..1671589 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF59_RS07875 (1671837) 1671837..1672589 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF59_RS07880 (1672689) 1672689..1672766 - 78 Protein_1517 porin family protein -
LJF59_RS07885 (1673146) 1673146..1673220 + 75 Protein_1518 helix-turn-helix domain-containing protein -
LJF59_RS07895 (1673491) 1673491..1674066 - 576 WP_001188509.1 transcriptional regulator -
LJF59_RS07900 (1674103) 1674103..1675806 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF59_RS07905 (1675782) 1675782..1676129 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221390 WP_000626100.1 NZ_CP085795:1671098-1671589 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221390 NZ_CP117386:3684881-3685138 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGTCCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221390 WP_001110452.1 NZ_CP085795:1670808-1671101 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221390 NZ_CP117386:c3685056-3684724 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References