Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1670808..1671589 | Replicon | chromosome |
| Accession | NZ_CP085795 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | LJF59_RS07870 | Protein ID | WP_000626100.1 |
| Coordinates | 1671098..1671589 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | LJF59_RS07865 | Protein ID | WP_001110452.1 |
| Coordinates | 1670808..1671101 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF59_RS07830 (1666855) | 1666855..1667760 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| LJF59_RS07835 (1668054) | 1668054..1668185 | - | 132 | Protein_1508 | hypothetical protein | - |
| LJF59_RS07840 (1668297) | 1668297..1668545 | - | 249 | Protein_1509 | Ig-like domain-containing protein | - |
| LJF59_RS07845 (1668544) | 1668544..1668852 | + | 309 | WP_072095651.1 | ABC transporter ATP-binding protein | - |
| LJF59_RS07850 (1668845) | 1668845..1669132 | - | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| LJF59_RS07855 (1669129) | 1669129..1670004 | - | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| LJF59_RS07860 (1670270) | 1670270..1670491 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| LJF59_RS07865 (1670808) | 1670808..1671101 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| LJF59_RS07870 (1671098) | 1671098..1671589 | + | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| LJF59_RS07875 (1671837) | 1671837..1672589 | - | 753 | WP_000842433.1 | non-specific acid phosphatase | - |
| LJF59_RS07880 (1672689) | 1672689..1672766 | - | 78 | Protein_1517 | porin family protein | - |
| LJF59_RS07885 (1673146) | 1673146..1673220 | + | 75 | Protein_1518 | helix-turn-helix domain-containing protein | - |
| LJF59_RS07895 (1673491) | 1673491..1674066 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
| LJF59_RS07900 (1674103) | 1674103..1675806 | - | 1704 | WP_000068885.1 | protein-disulfide reductase DsbD | - |
| LJF59_RS07905 (1675782) | 1675782..1676129 | - | 348 | WP_000887832.1 | divalent cation tolerance protein CutA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T221390 WP_000626100.1 NZ_CP085795:1671098-1671589 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T221390 NZ_CP117386:3684881-3685138 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGTCCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGTCCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT221390 WP_001110452.1 NZ_CP085795:1670808-1671101 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT221390 NZ_CP117386:c3685056-3684724 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |