Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 970175..970935 Replicon chromosome
Accession NZ_CP085795
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF59_RS04660 Protein ID WP_000533912.1
Coordinates 970175..970660 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF59_RS04665 Protein ID WP_000965886.1
Coordinates 970648..970935 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF59_RS04630 (965247) 965247..965909 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF59_RS04635 (966128) 966128..967102 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF59_RS04640 (967152) 967152..967862 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF59_RS04645 (968301) 968301..968591 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF59_RS04650 (968879) 968879..969091 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF59_RS04655 (969265) 969265..969804 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF59_RS04660 (970175) 970175..970660 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF59_RS04665 (970648) 970648..970935 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF59_RS04670 (971113) 971113..971580 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF59_RS04675 (971752) 971752..972150 - 399 Protein_904 IS3 family transposase -
LJF59_RS04680 (972540) 972540..974609 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF59_RS04685 (974619) 974619..975530 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221387 WP_000533912.1 NZ_CP085795:c970660-970175 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221387 NZ_CP117386:c2473825-2473722 [Salmonella enterica subsp. enterica serovar Uganda]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221387 WP_000965886.1 NZ_CP085795:c970935-970648 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221387 NZ_CP117386:2473720-2473863 [Salmonella enterica subsp. enterica serovar Uganda]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References