Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 345431..346091 Replicon chromosome
Accession NZ_CP085795
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF59_RS01615 Protein ID WP_000244756.1
Coordinates 345431..345844 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF59_RS01620 Protein ID WP_000351186.1
Coordinates 345825..346091 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF59_RS01595 (341372) 341372..343105 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
LJF59_RS01600 (343111) 343111..343824 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF59_RS01605 (343848) 343848..344744 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF59_RS01610 (344857) 344857..345378 + 522 WP_001055885.1 flavodoxin FldB -
LJF59_RS01615 (345431) 345431..345844 - 414 WP_000244756.1 protein YgfX Toxin
LJF59_RS01620 (345825) 345825..346091 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF59_RS01625 (346341) 346341..347321 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF59_RS01630 (347437) 347437..348096 - 660 WP_000250289.1 hemolysin III family protein -
LJF59_RS01635 (348260) 348260..348571 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF59_RS01640 (348729) 348729..350162 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221384 WP_000244756.1 NZ_CP085795:c345844-345431 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221384 NZ_CP117386:849261-849659 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGCCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221384 WP_000351186.1 NZ_CP085795:c346091-345825 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221384 NZ_CP117386:849034-849261 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References