Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 334542..335167 Replicon chromosome
Accession NZ_CP085795
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)


Gene name vapC Uniprot ID M7SD17
Locus tag LJF59_RS01550 Protein ID WP_000911336.1
Coordinates 334542..334940 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag LJF59_RS01555 Protein ID WP_000557549.1
Coordinates 334940..335167 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF59_RS01535 (331219) 331219..331800 - 582 WP_001244651.1 fimbrial protein -
LJF59_RS01540 (332519) 332519..333151 - 633 WP_000835265.1 YfdX family protein -
LJF59_RS01545 (333198) 333198..333734 - 537 WP_001038502.1 STM3031 family outer membrane protein -
LJF59_RS01550 (334542) 334542..334940 - 399 WP_000911336.1 tRNA(fMet)-specific endonuclease VapC Toxin
LJF59_RS01555 (334940) 334940..335167 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
LJF59_RS01560 (335376) 335376..335627 + 252 WP_001576352.1 hypothetical protein -
LJF59_RS01565 (335907) 335907..336713 + 807 WP_001574939.1 DUF1460 domain-containing protein -
LJF59_RS01575 (336998) 336998..337756 - 759 WP_000244328.1 amidase activator ActS -
LJF59_RS01580 (338021) 338021..338566 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
LJF59_RS01585 (338642) 338642..340159 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14938.30 Da        Isoelectric Point: 7.2155

>T221383 WP_000911336.1 NZ_CP085795:c334940-334542 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T221383 NZ_CP117386:839553-839966 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT221383 WP_000557549.1 NZ_CP085795:c335167-334940 [Salmonella enterica subsp. enterica serovar Enteritidis]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT221383 NZ_CP117386:839306-839572 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6IFC
PDB 6IFM

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References