Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2438524..2439144 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF60_RS11520 Protein ID WP_001280991.1
Coordinates 2438524..2438742 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF60_RS11525 Protein ID WP_000344807.1
Coordinates 2438770..2439144 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS11480 (2433747) 2433747..2434316 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF60_RS11485 (2434349) 2434349..2434738 - 390 WP_000961287.1 MGMT family protein -
LJF60_RS11495 (2434969) 2434969..2436519 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF60_RS11500 (2436744) 2436744..2437004 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF60_RS11505 (2437010) 2437010..2437150 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF60_RS11510 (2437206) 2437206..2437676 - 471 WP_000136183.1 YlaC family protein -
LJF60_RS11515 (2437794) 2437794..2438345 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF60_RS11520 (2438524) 2438524..2438742 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF60_RS11525 (2438770) 2438770..2439144 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF60_RS11530 (2439640) 2439640..2442789 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF60_RS11535 (2442812) 2442812..2444005 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221371 WP_001280991.1 NZ_CP085794:c2438742-2438524 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221371 NZ_CP117384:2019544-2019647 [Salmonella enterica subsp. enterica serovar Uganda]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221371 WP_000344807.1 NZ_CP085794:c2439144-2438770 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221371 NZ_CP117384:c2019649-2019506 [Salmonella enterica subsp. enterica serovar Uganda]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References