Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1863174..1863750 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF60_RS08870 Protein ID WP_001131963.1
Coordinates 1863174..1863461 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF60_RS08875 Protein ID WP_000063142.1
Coordinates 1863448..1863750 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS08855 (1860034) 1860034..1861338 - 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -
LJF60_RS08860 (1861328) 1861328..1861507 - 180 Protein_1707 DNA methyltransferase -
LJF60_RS08865 (1861501) 1861501..1862757 - 1257 Protein_1708 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF60_RS08870 (1863174) 1863174..1863461 + 288 WP_001131963.1 BrnT family toxin Toxin
LJF60_RS08875 (1863448) 1863448..1863750 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF60_RS08880 (1863825) 1863825..1864781 - 957 WP_000187843.1 GTPase -
LJF60_RS08885 (1864792) 1864792..1864995 - 204 WP_000460616.1 YbdD/YjiX family protein -
LJF60_RS08890 (1865090) 1865090..1867240 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221367 WP_001131963.1 NZ_CP085794:1863174-1863461 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221367 NZ_CP117384:839710-840123 [Salmonella enterica subsp. enterica serovar Uganda]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221367 WP_000063142.1 NZ_CP085794:1863448-1863750 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221367 NZ_CP117384:839463-839729 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References