Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1670687..1671468 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF60_RS07865 Protein ID WP_000626100.1
Coordinates 1670977..1671468 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF60_RS07860 Protein ID WP_001110452.1
Coordinates 1670687..1670980 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS07825 (1666734) 1666734..1667639 + 906 WP_001268200.1 YjiK family protein -
LJF60_RS07830 (1667933) 1667933..1668064 - 132 Protein_1508 hypothetical protein -
LJF60_RS07835 (1668176) 1668176..1668424 - 249 Protein_1509 Ig-like domain-containing protein -
LJF60_RS07840 (1668423) 1668423..1668731 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF60_RS07845 (1668724) 1668724..1669011 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF60_RS07850 (1669008) 1669008..1669883 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF60_RS07855 (1670149) 1670149..1670370 - 222 WP_001576552.1 hypothetical protein -
LJF60_RS07860 (1670687) 1670687..1670980 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF60_RS07865 (1670977) 1670977..1671468 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF60_RS07870 (1671716) 1671716..1672468 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF60_RS07875 (1672568) 1672568..1672645 - 78 Protein_1517 porin family protein -
LJF60_RS07880 (1673025) 1673025..1673099 + 75 Protein_1518 helix-turn-helix domain-containing protein -
LJF60_RS07890 (1673370) 1673370..1673945 - 576 WP_001188509.1 transcriptional regulator -
LJF60_RS07895 (1673982) 1673982..1675685 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF60_RS07900 (1675661) 1675661..1676008 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221364 WP_000626100.1 NZ_CP085794:1670977-1671468 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221364 NZ_CP117382:4615489-4615800 [Salmonella enterica subsp. enterica serovar Uganda]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTAGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221364 WP_001110452.1 NZ_CP085794:1670687-1670980 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221364 NZ_CP117382:4615797-4616243 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References