Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 860095..860681 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name doc Uniprot ID A0A3V9X0E4
Locus tag LJF60_RS04170 Protein ID WP_000174964.1
Coordinates 860095..860463 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag LJF60_RS04175 Protein ID WP_001522145.1
Coordinates 860460..860681 (-) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS04150 (855614) 855614..856684 - 1071 WP_000907840.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
LJF60_RS04155 (856686) 856686..857531 - 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LJF60_RS04160 (857528) 857528..858415 - 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LJF60_RS04165 (858520) 858520..859836 - 1317 WP_000624755.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LJF60_RS04170 (860095) 860095..860463 - 369 WP_000174964.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LJF60_RS04175 (860460) 860460..860681 - 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF60_RS04180 (860812) 860812..861525 - 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LJF60_RS04185 (861527) 861527..862294 - 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LJF60_RS04190 (862291) 862291..863568 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
LJF60_RS04195 (863565) 863565..864491 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LJF60_RS04200 (864551) 864551..865660 - 1110 WP_000822978.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 854877..863568 8691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13601.91 Da        Isoelectric Point: 6.7252

>T221360 WP_000174964.1 NZ_CP085794:c860463-860095 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

>T221360 NZ_CP117382:3690478-3690735 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCACCTTAAGGGTGACTGGCTGGAAGAAGCGGGATTTGAGACCGGGCGCGGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT221360 WP_001522145.1 NZ_CP085794:c860681-860460 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT221360 NZ_CP117382:c3690653-3690385 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V9X0E4


Antitoxin

Source ID Structure

References