Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 345304..345964 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF60_RS01610 Protein ID WP_000244756.1
Coordinates 345304..345717 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF60_RS01615 Protein ID WP_000351186.1
Coordinates 345698..345964 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS01590 (341245) 341245..342978 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
LJF60_RS01595 (342984) 342984..343697 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF60_RS01600 (343721) 343721..344617 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF60_RS01605 (344730) 344730..345251 + 522 WP_001055885.1 flavodoxin FldB -
LJF60_RS01610 (345304) 345304..345717 - 414 WP_000244756.1 protein YgfX Toxin
LJF60_RS01615 (345698) 345698..345964 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF60_RS01620 (346214) 346214..347194 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF60_RS01625 (347310) 347310..347969 - 660 WP_000250289.1 hemolysin III family protein -
LJF60_RS01630 (348133) 348133..348444 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF60_RS01635 (348602) 348602..350035 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221358 WP_000244756.1 NZ_CP085794:c345717-345304 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221358 NZ_CP117382:3685149-3685406 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGTCCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221358 WP_000351186.1 NZ_CP085794:c345964-345698 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221358 NZ_CP117382:c3685324-3684992 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References