Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1122782..1123402 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF61_RS05230 Protein ID WP_001280991.1
Coordinates 1122782..1123000 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF61_RS05235 Protein ID WP_000344807.1
Coordinates 1123028..1123402 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS05190 (1118005) 1118005..1118574 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF61_RS05195 (1118607) 1118607..1118996 - 390 WP_000961287.1 MGMT family protein -
LJF61_RS05205 (1119227) 1119227..1120777 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF61_RS05210 (1121002) 1121002..1121262 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF61_RS05215 (1121268) 1121268..1121408 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF61_RS05220 (1121464) 1121464..1121934 - 471 WP_000136183.1 YlaC family protein -
LJF61_RS05225 (1122052) 1122052..1122603 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF61_RS05230 (1122782) 1122782..1123000 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF61_RS05235 (1123028) 1123028..1123402 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF61_RS05240 (1123898) 1123898..1127047 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF61_RS05245 (1127070) 1127070..1128263 - 1194 WP_227784346.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221339 WP_001280991.1 NZ_CP085793:c1123000-1122782 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221339 NZ_CP117380:312735-313103 [Salmonella enterica subsp. enterica serovar Newport]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221339 WP_000344807.1 NZ_CP085793:c1123402-1123028 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221339 NZ_CP117380:312517-312738 [Salmonella enterica subsp. enterica serovar Newport]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References