Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 503065..503615 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF61_RS02370 Protein ID WP_001199743.1
Coordinates 503307..503615 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF61_RS02365 Protein ID WP_001118105.1
Coordinates 503065..503304 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS02330 (498504) 498504..499535 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF61_RS02335 (499752) 499752..500282 + 531 WP_000896758.1 gluconokinase -
LJF61_RS02340 (500310) 500310..501329 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF61_RS02355 (502086) 502086..502631 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF61_RS02360 (502708) 502708..502956 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF61_RS02365 (503065) 503065..503304 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF61_RS02370 (503307) 503307..503615 + 309 WP_001199743.1 CcdB family protein Toxin
LJF61_RS02375 (504021) 504021..504161 + 141 Protein_449 Arm DNA-binding domain-containing protein -
LJF61_RS02380 (504193) 504193..505326 - 1134 Protein_450 IS3 family transposase -
LJF61_RS02385 (505649) 505649..506179 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF61_RS02390 (506301) 506301..507041 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 503065..523558 20493
- inside IScluster/Tn - - 502131..505234 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221334 WP_001199743.1 NZ_CP085793:503307-503615 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221334 NZ_CP117378:c4176210-4175926 [Salmonella enterica subsp. enterica serovar Newport]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATACAAACAAACGGCTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221334 WP_001118105.1 NZ_CP085793:503065-503304 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221334 NZ_CP117378:c4176442-4176200 [Salmonella enterica subsp. enterica serovar Newport]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References