Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 461964..462480 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF61_RS02150 Protein ID WP_000220582.1
Coordinates 462196..462480 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF61_RS02145 Protein ID WP_000212724.1
Coordinates 461964..462206 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS02125 (456984) 456984..458117 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LJF61_RS02130 (458101) 458101..459219 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF61_RS02135 (459216) 459216..459956 + 741 WP_000779259.1 KDGP aldolase family protein -
LJF61_RS02140 (459973) 459973..461886 + 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF61_RS02145 (461964) 461964..462206 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF61_RS02150 (462196) 462196..462480 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF61_RS02155 (462484) 462484..462948 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF61_RS02160 (463070) 463070..465208 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF61_RS02165 (465617) 465617..467269 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221333 WP_000220582.1 NZ_CP085793:462196-462480 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221333 NZ_CP117378:3677594-3677869 [Salmonella enterica subsp. enterica serovar Newport]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATCTCCAAGGGATGTT
TGATCCTGATGGCTGAGACGGACGAAGTGAGGGAGCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATGATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221333 WP_000212724.1 NZ_CP085793:461964-462206 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221333 NZ_CP117378:c3677859-3677437 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References