Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 354803..355584 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF61_RS01575 Protein ID WP_000626100.1
Coordinates 355093..355584 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF61_RS01570 Protein ID WP_001110452.1
Coordinates 354803..355096 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS01535 (350850) 350850..351755 + 906 WP_001268200.1 YjiK family protein -
LJF61_RS01540 (352049) 352049..352180 - 132 Protein_289 hypothetical protein -
LJF61_RS01545 (352292) 352292..352540 - 249 Protein_290 Ig-like domain-containing protein -
LJF61_RS01550 (352539) 352539..352847 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF61_RS01555 (352840) 352840..353127 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF61_RS01560 (353124) 353124..353999 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF61_RS01565 (354265) 354265..354486 - 222 WP_001576552.1 hypothetical protein -
LJF61_RS01570 (354803) 354803..355096 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF61_RS01575 (355093) 355093..355584 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF61_RS01580 (355832) 355832..356584 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF61_RS01585 (356684) 356684..356761 - 78 Protein_298 porin family protein -
LJF61_RS01590 (357141) 357141..357215 + 75 Protein_299 helix-turn-helix domain-containing protein -
LJF61_RS01600 (357486) 357486..358061 - 576 WP_001188509.1 transcriptional regulator -
LJF61_RS01605 (358098) 358098..359801 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF61_RS01610 (359777) 359777..360124 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(85-145)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221332 WP_000626100.1 NZ_CP085793:355093-355584 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221332 NZ_CP117378:3486520-3486738 [Salmonella enterica subsp. enterica serovar Newport]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221332 WP_001110452.1 NZ_CP085793:354803-355096 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221332 NZ_CP117378:3486118-3486492 [Salmonella enterica subsp. enterica serovar Newport]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A656IQ80


Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References