Detailed information of TA system TA221319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2879686..2880306
• Replicon: chromosome
• Accession: NZ_CP085792
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJF62_RS13600
• Protein ID: WP_001280991.1
• Coordinates: 2879686..2879904 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LJF62_RS13605
• Protein ID: WP_000344807.1
• Coordinates: 2879932..2880306 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF62_RS13560 (2874909)	2874909..2875478	+	570	WP_000779802.1	YbaY family lipoprotein	-
LJF62_RS13565 (2875511)	2875511..2875900	-	390	WP_000961287.1	MGMT family protein	-
LJF62_RS13575 (2876131)	2876131..2877681	-	1551	WP_000213140.1	EAL domain-containing protein	-
LJF62_RS13580 (2877906)	2877906..2878166	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJF62_RS13585 (2878172)	2878172..2878312	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJF62_RS13590 (2878368)	2878368..2878838	-	471	WP_000136183.1	YlaC family protein	-
LJF62_RS13595 (2878956)	2878956..2879507	-	552	WP_001278793.1	maltose O-acetyltransferase	-
LJF62_RS13600 (2879686)	2879686..2879904	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJF62_RS13605 (2879932)	2879932..2880306	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LJF62_RS13610 (2880802)	2880802..2883951	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LJF62_RS13615 (2883974)	2883974..2885167	-	1194	WP_227784346.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221319 WP_001280991.1 NZ_CP085792:c2879904-2879686 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221319 NZ_CP117376:c991485-990958 [Salmonella enterica subsp. enterica serovar Newport]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT221319 WP_000344807.1 NZ_CP085792:c2880306-2879932 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT221319 NZ_CP117376:c991772-991482 [Salmonella enterica subsp. enterica serovar Newport]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0