Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2259969..2260519 Replicon chromosome
Accession NZ_CP085792
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF62_RS10740 Protein ID WP_001199743.1
Coordinates 2260211..2260519 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF62_RS10735 Protein ID WP_001118105.1
Coordinates 2259969..2260208 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF62_RS10700 (2255408) 2255408..2256439 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF62_RS10705 (2256656) 2256656..2257186 + 531 WP_000896758.1 gluconokinase -
LJF62_RS10710 (2257214) 2257214..2258233 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF62_RS10725 (2258990) 2258990..2259535 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF62_RS10730 (2259612) 2259612..2259860 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF62_RS10735 (2259969) 2259969..2260208 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF62_RS10740 (2260211) 2260211..2260519 + 309 WP_001199743.1 CcdB family protein Toxin
LJF62_RS10745 (2260925) 2260925..2261065 + 141 Protein_2077 Arm DNA-binding domain-containing protein -
LJF62_RS10750 (2261097) 2261097..2262230 - 1134 Protein_2078 IS3 family transposase -
LJF62_RS10755 (2262553) 2262553..2263083 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF62_RS10760 (2263205) 2263205..2263945 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2259035..2262138 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221314 WP_001199743.1 NZ_CP085792:2260211-2260519 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221314 NZ_CP117375:13321-13626 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221314 WP_001118105.1 NZ_CP085792:2259969-2260208 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221314 NZ_CP117375:13101-13319 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References