Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2218878..2219394 Replicon chromosome
Accession NZ_CP085792
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF62_RS10520 Protein ID WP_000220582.1
Coordinates 2219110..2219394 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF62_RS10515 Protein ID WP_000212724.1
Coordinates 2218878..2219120 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF62_RS10495 (2213898) 2213898..2215031 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LJF62_RS10500 (2215015) 2215015..2216133 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF62_RS10505 (2216130) 2216130..2216870 + 741 WP_000779259.1 KDGP aldolase family protein -
LJF62_RS10510 (2216887) 2216887..2218800 + 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF62_RS10515 (2218878) 2218878..2219120 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF62_RS10520 (2219110) 2219110..2219394 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF62_RS10525 (2219398) 2219398..2219862 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF62_RS10530 (2219984) 2219984..2222122 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF62_RS10535 (2222531) 2222531..2224183 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221313 WP_000220582.1 NZ_CP085792:2219110-2219394 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221313 NZ_CP117375:c12129-11701 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGCAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221313 WP_000212724.1 NZ_CP085792:2218878-2219120 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221313 NZ_CP117375:c12356-12126 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References