Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2111717..2112498 | Replicon | chromosome |
| Accession | NZ_CP085792 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | LJF62_RS09945 | Protein ID | WP_000626100.1 |
| Coordinates | 2112007..2112498 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | LJF62_RS09940 | Protein ID | WP_001110452.1 |
| Coordinates | 2111717..2112010 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF62_RS09905 (2107764) | 2107764..2108669 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| LJF62_RS09910 (2108963) | 2108963..2109094 | - | 132 | Protein_1917 | hypothetical protein | - |
| LJF62_RS09915 (2109206) | 2109206..2109454 | - | 249 | Protein_1918 | Ig-like domain-containing protein | - |
| LJF62_RS09920 (2109453) | 2109453..2109761 | + | 309 | WP_072095651.1 | ABC transporter ATP-binding protein | - |
| LJF62_RS09925 (2109754) | 2109754..2110041 | - | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| LJF62_RS09930 (2110038) | 2110038..2110913 | - | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| LJF62_RS09935 (2111179) | 2111179..2111400 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| LJF62_RS09940 (2111717) | 2111717..2112010 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| LJF62_RS09945 (2112007) | 2112007..2112498 | + | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| LJF62_RS09950 (2112746) | 2112746..2113498 | - | 753 | WP_000842433.1 | non-specific acid phosphatase | - |
| LJF62_RS09955 (2113598) | 2113598..2113675 | - | 78 | Protein_1926 | porin family protein | - |
| LJF62_RS09960 (2114055) | 2114055..2114129 | + | 75 | Protein_1927 | helix-turn-helix domain-containing protein | - |
| LJF62_RS09970 (2114400) | 2114400..2114975 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
| LJF62_RS09975 (2115012) | 2115012..2116715 | - | 1704 | WP_000068885.1 | protein-disulfide reductase DsbD | - |
| LJF62_RS09980 (2116691) | 2116691..2117038 | - | 348 | WP_000887832.1 | divalent cation tolerance protein CutA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T221312 WP_000626100.1 NZ_CP085792:2112007-2112498 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T221312 NZ_CP117374:c14266-13916 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT221312 WP_001110452.1 NZ_CP085792:2111717-2112010 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT221312 NZ_CP117374:c13911-13609 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |