Detailed information of TA system TA022131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4886540..4887174
• Replicon: chromosome
• Accession: NC_009523
• Organism: Roseiflexus sp. RS-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A5V055
• Locus tag: ROSERS_RS20120
• Protein ID: WP_011958598.1
• Coordinates: 4886540..4886944 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A5V056
• Locus tag: ROSERS_RS20125
• Protein ID: WP_011958599.1
• Coordinates: 4886941..4887174 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ROSERS_RS20090	4881721..4882167	-	447	WP_011958592.1	FixH family protein	-
ROSERS_RS20095	4882276..4883271	-	996	WP_011958593.1	flippase-like domain-containing protein	-
ROSERS_RS20100	4883268..4884203	-	936	WP_011958594.1	glycosyltransferase family 2 protein	-
ROSERS_RS20105	4884356..4884973	-	618	WP_011958595.1	bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH	-
ROSERS_RS20110	4885176..4885805	+	630	WP_157041168.1	hypothetical protein	-
ROSERS_RS20115	4885802..4886146	+	345	WP_011958597.1	hypothetical protein	-
ROSERS_RS20120	4886540..4886944	-	405	WP_011958598.1	type II toxin-antitoxin system VapC family toxin	Toxin
ROSERS_RS20125	4886941..4887174	-	234	WP_011958599.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ROSERS_RS20130	4887617..4889746	-	2130	WP_041335880.1	glycosyltransferase family 39 protein	-
ROSERS_RS20135	4889791..4892136	-	2346	WP_049767548.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-48)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14910.42 Da
• Isoelectric Point: 7.7786

>T22131 WP_011958598.1 NC_009523:c4886944-4886540 [Roseiflexus sp. RS-1]
MKYLLDTNICILLIRQKSQAVLQRLTRLPLTDVAVSAITVAELRYGVAKSRYVAQNQQALDYFLLPLTILPFDEKSAMTY
GEIRAFLEAQGTPIGAIDTLLAAQAVSCRLILVTNNVREFARVPGLTVEDWSQP

Nucleotide

• Length: 405 bp

>T22131 NC_009523:c4886944-4886540 [Roseiflexus sp. RS-1]
ATGAAATATCTGCTGGACACAAACATCTGTATCCTGCTTATTCGACAAAAGTCGCAGGCCGTCTTACAGAGACTTACACG
GCTGCCCCTGACCGATGTGGCCGTCTCAGCGATTACAGTCGCTGAACTCCGGTATGGCGTTGCGAAGAGCAGATATGTTG
CCCAAAACCAACAGGCGCTTGATTACTTTCTGTTGCCCTTGACGATCTTGCCTTTTGATGAGAAGTCTGCGATGACCTAT
GGAGAGATACGCGCCTTTCTTGAAGCGCAAGGAACACCGATAGGCGCGATTGATACCTTGCTCGCGGCTCAGGCGGTCAG
CTGCAGGCTCATTCTGGTGACCAACAATGTGCGGGAATTCGCGCGTGTGCCGGGGTTGACGGTCGAGGATTGGTCACAGC
CGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9210.50 Da
• Isoelectric Point: 5.8150

>AT22131 WP_011958599.1 NC_009523:c4887174-4886941 [Roseiflexus sp. RS-1]
MDTARIFRNGQSQAIRLPKEYRFRGDRVYLKRMGNAVVLLPEYDSWQTLIESLSMFSDDFMAERDQPPIQVREHLFE

Nucleotide

• Length: 234 bp

>AT22131 NC_009523:c4887174-4886941 [Roseiflexus sp. RS-1]
ATGGACACCGCCAGGATTTTCCGGAATGGTCAGAGCCAGGCCATCCGTCTGCCGAAAGAGTATCGGTTCCGCGGCGACAG
AGTCTATCTCAAGCGCATGGGCAATGCAGTCGTGCTTCTTCCCGAGTACGACTCATGGCAAACGCTCATCGAGAGTCTGT
CCATGTTCTCCGACGACTTTATGGCTGAACGCGATCAGCCTCCCATCCAGGTACGTGAACATCTGTTTGAATGA

Structures

Toxin

• AlphaFold DB: A5V055

Antitoxin

• AlphaFold DB: A5V056