Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3580792..3581445 Replicon chromosome
Accession NZ_CP085788
Organism Acinetobacter baumannii strain RCH52

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J8TGE7
Locus tag NLHDIDDJ_RS17095 Protein ID WP_024437032.1
Coordinates 3580792..3581181 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag NLHDIDDJ_RS17100 Protein ID WP_001288210.1
Coordinates 3581188..3581445 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLHDIDDJ_RS17080 (NLHDIDDJ_03393) 3575911..3578106 - 2196 WP_213702298.1 TRAP transporter large permease subunit -
NLHDIDDJ_RS17085 (NLHDIDDJ_03394) 3578294..3578860 - 567 WP_000651536.1 rhombosortase -
NLHDIDDJ_RS17090 (NLHDIDDJ_03395) 3578938..3580023 - 1086 WP_228413416.1 hypothetical protein -
NLHDIDDJ_RS17095 (NLHDIDDJ_03397) 3580792..3581181 - 390 WP_024437032.1 membrane protein Toxin
NLHDIDDJ_RS17100 (NLHDIDDJ_03398) 3581188..3581445 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
NLHDIDDJ_RS17105 (NLHDIDDJ_03399) 3581633..3582805 + 1173 WP_225546104.1 acyl-CoA dehydrogenase family protein -
NLHDIDDJ_RS17110 (NLHDIDDJ_03400) 3582854..3584344 - 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
NLHDIDDJ_RS17115 (NLHDIDDJ_03401) 3584526..3584903 - 378 WP_001216380.1 50S ribosomal protein L17 -
NLHDIDDJ_RS17120 (NLHDIDDJ_03402) 3584922..3585929 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15584.82 Da        Isoelectric Point: 10.3889

>T221302 WP_024437032.1 NZ_CP085788:c3581181-3580792 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAALFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T221302 NZ_CP117373:c991389-990862 [Salmonella enterica subsp. enterica serovar Dublin]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT221302 WP_001288210.1 NZ_CP085788:c3581445-3581188 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT221302 NZ_CP117373:c991676-991386 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TGE7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References