Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 529894..530516 | Replicon | chromosome |
| Accession | NZ_CP085788 | ||
| Organism | Acinetobacter baumannii strain RCH52 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | NLHDIDDJ_RS02505 | Protein ID | WP_140948450.1 |
| Coordinates | 529894..530289 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | NLHDIDDJ_RS02510 | Protein ID | WP_104427085.1 |
| Coordinates | 530286..530516 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NLHDIDDJ_RS02480 | 525574..526371 | + | 798 | Protein_473 | class I SAM-dependent DNA methyltransferase | - |
| NLHDIDDJ_RS02490 (NLHDIDDJ_00495) | 527596..528417 | + | 822 | WP_085562421.1 | OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-565 | - |
| NLHDIDDJ_RS02495 (NLHDIDDJ_00496) | 528522..529181 | - | 660 | Protein_476 | ATP-binding protein | - |
| NLHDIDDJ_RS02500 (NLHDIDDJ_00497) | 529144..529812 | + | 669 | WP_213702720.1 | hypothetical protein | - |
| NLHDIDDJ_RS02505 (NLHDIDDJ_00498) | 529894..530289 | - | 396 | WP_140948450.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| NLHDIDDJ_RS02510 (NLHDIDDJ_00499) | 530286..530516 | - | 231 | WP_104427085.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| NLHDIDDJ_RS02515 (NLHDIDDJ_00500) | 531170..531595 | + | 426 | WP_065995587.1 | DUF6530 family protein | - |
| NLHDIDDJ_RS02520 (NLHDIDDJ_00501) | 531779..531922 | - | 144 | WP_171476913.1 | hypothetical protein | - |
| NLHDIDDJ_RS02525 (NLHDIDDJ_00502) | 531935..532489 | - | 555 | WP_136144359.1 | plasmid replication DNA-binding protein | - |
| NLHDIDDJ_RS02530 | 532482..532610 | - | 129 | Protein_483 | RepB family plasmid replication initiator protein | - |
| NLHDIDDJ_RS02535 (NLHDIDDJ_00503) | 532664..533368 | - | 705 | WP_001067784.1 | IS6-like element IS1006 family transposase | - |
| NLHDIDDJ_RS02540 | 533432..534262 | + | 831 | Protein_485 | IS91-like element ISVsa3 family transposase | - |
| NLHDIDDJ_RS02545 | 534353..535180 | - | 828 | WP_228413704.1 | DNA topoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | blaOXA-565 / floR / sul2 / dfrA14 / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / qacE / sul1 / blaSCO-1 / aac(3)-IIa / blaTEM-1B / aph(3')-Ia | - | 457016..756554 | 299538 | |
| - | inside | IScluster/Tn | blaOXA-565 / floR / sul2 | - | 521925..541963 | 20038 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14925.20 Da Isoelectric Point: 6.2238
>T221301 WP_140948450.1 NZ_CP085788:c530289-529894 [Acinetobacter baumannii]
MIYLLDTNICIYVINHKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLDILPYDEQAIWHYA
KLRQDLQSTGKTIGSLDMLIAAHALALDVVLVTNNIKEFERIDGLKLENWT
MIYLLDTNICIYVINHKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLDILPYDEQAIWHYA
KLRQDLQSTGKTIGSLDMLIAAHALALDVVLVTNNIKEFERIDGLKLENWT
Download Length: 396 bp
>T221301 NZ_CP117373:835164-835562 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8733.00 Da Isoelectric Point: 4.7708
>AT221301 WP_104427085.1 NZ_CP085788:c530516-530286 [Acinetobacter baumannii]
METAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIENPWDIMLEAINEFEVGFQLERADQGEQLREDFK
METAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIENPWDIMLEAINEFEVGFQLERADQGEQLREDFK
Download Length: 231 bp
>AT221301 NZ_CP117373:834937-835164 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|