Detailed information of TA system TA221297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4644107..4644723
• Replicon: chromosome
• Accession: NZ_CP085780
• Organism: Enterobacter hormaechei strain 48411CZ

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LJU35_RS22495
• Protein ID: WP_015569913.1
• Coordinates: 4644107..4644478 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: LJU35_RS22500
• Protein ID: WP_015569912.1
• Coordinates: 4644481..4644723 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU35_RS22480 (LJU35_22480)	4641607..4642509	+	903	WP_014072386.1	formate dehydrogenase subunit beta	-
LJU35_RS22485 (LJU35_22485)	4642506..4643141	+	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
LJU35_RS22490 (LJU35_22490)	4643138..4644067	+	930	WP_003861956.1	formate dehydrogenase accessory protein FdhE	-
LJU35_RS22495 (LJU35_22495)	4644107..4644478	-	372	WP_015569913.1	PIN domain-containing protein	Toxin
LJU35_RS22500 (LJU35_22500)	4644481..4644723	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
LJU35_RS22505 (LJU35_22505)	4644922..4645842	+	921	WP_015569911.1	alpha/beta hydrolase	-
LJU35_RS22510 (LJU35_22510)	4645851..4646792	-	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
LJU35_RS22515 (LJU35_22515)	4646837..4647274	-	438	WP_015569909.1	D-aminoacyl-tRNA deacylase	-
LJU35_RS22520 (LJU35_22520)	4647271..4648152	-	882	WP_003861949.1	virulence factor BrkB family protein	-
LJU35_RS22525 (LJU35_22525)	4648146..4648745	-	600	WP_017694048.1	glucose-1-phosphatase	-
LJU35_RS22530 (LJU35_22530)	4648864..4649664	-	801	WP_045344666.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13767.90 Da
• Isoelectric Point: 6.4882

>T221297 WP_015569913.1 NZ_CP085780:c4644478-4644107 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVSARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T221297 NZ_CP117373:200049-200534 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT221297 WP_015569912.1 NZ_CP085780:c4644723-4644481 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT221297 NZ_CP117373:199774-200061 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3