Detailed information of TA system TA022129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PsyrTA/-
• Location: 3552613..3554198
• Replicon: chromosome
• Accession: NC_009523
• Organism: Roseiflexus sp. RS-1

Toxin (Protein)

• Gene name: PsyrT
• Uniprot ID: -
• Locus tag: ROSERS_RS14645
• Protein ID: WP_083763304.1
• Coordinates: 3552613..3552837 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: PsyrA
• Uniprot ID: A5UX61
• Locus tag: ROSERS_RS14650
• Protein ID: WP_011957558.1
• Coordinates: 3552834..3554198 (+)
• Length: 455 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ROSERS_RS14635	3548906..3549868	-	963	WP_011957556.1	IS110-like element ISRfsp2 family transposase	-
ROSERS_RS14640	3550577..3552616	+	2040	WP_157041095.1	PAS domain S-box protein	-
ROSERS_RS14645	3552613..3552837	+	225	WP_083763304.1	hypothetical protein	Toxin
ROSERS_RS14650	3552834..3554198	+	1365	WP_011957558.1	DNA-protecting protein DprA	Antitoxin
ROSERS_RS14655	3554182..3556806	-	2625	WP_011957559.1	CBS domain-containing protein	-
ROSERS_RS14660	3556797..3557228	-	432	WP_011957560.1	hypothetical protein	-
ROSERS_RS14665	3557222..3558271	-	1050	WP_011957561.1	Gfo/Idh/MocA family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3548906..3549868	962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• DNA recombination-mediator protein A (93-258)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8732.22 Da
• Isoelectric Point: 11.3246

>T22129 WP_083763304.1 NC_009523:3552613-3552837 [Roseiflexus sp. RS-1]
MMELHRYAGQLLKRMLNNPAATFRDGQWEAIADLVERKARLLVVQRTGCCGKPAVVRSFRWRWRWCSRDERGAL

Nucleotide

• Length: 225 bp

>T22129 NC_009523:3552613-3552837 [Roseiflexus sp. RS-1]
ATGATGGAGCTGCACCGATACGCTGGACAACTGCTGAAGCGGATGCTCAACAATCCGGCTGCAACCTTTCGGGATGGTCA
GTGGGAAGCAATAGCCGATCTCGTTGAGCGAAAGGCGCGCCTGCTCGTTGTGCAACGCACCGGTTGTTGCGGGAAGCCGG
CAGTGGTCCGGTCTTTCCGCTGGCGCTGGCGCTGGTGCAGTCGAGATGAGAGGGGAGCGTTATGA

Antitoxin

Protein

• Length: 455 a.a.
• Molecular weight: 48683.36 Da
• Isoelectric Point: 7.7425

>AT22129 WP_011957558.1 NC_009523:3552834-3554198 [Roseiflexus sp. RS-1]
MTGVELRPDTQAILLLCGTFGRHETGAAPLSPTEYHALALWLYAHQMRPGDLLLPDGASALRTSPDVPVNPERLTALLAR
GGALALSVEKWVNKGLWVMSRSDADYPQRLKTRLGRTAPPLLYGAGNRQLLGQGGLAILGSRNSAAHALAFTRRIAGMCA
RQGMPVLSGAARGVDSEAMQAALDARGVVIGVLADSLLKAAVGRNYRQAVRNGNLVLVSACDPEAGFTVGNAMGRNKYIY
ALSDYALVVSAALGEGGAWSGAVENLTKRWVPLFVWIDDESLPGNQRLRDMGALPFSENQCAGESVHDLFKRLADETTPQ
HVLSGNGMVASSNARASDGGHAEEQTASAGDQTKTNLSSEQQVLELTAVEANTSAPTVDLFPIVWPYLEQALYAAQTERE
LLYAAQTERELAQRCGIELTQARAWLQRAVQKGLVARLTRPTRYVIASPITRHA

Nucleotide

• Length: 1365 bp

>AT22129 NC_009523:3552834-3554198 [Roseiflexus sp. RS-1]
ATGACCGGAGTTGAGCTTCGTCCCGACACACAGGCTATTCTGCTTCTCTGCGGGACGTTTGGCAGACACGAAACAGGAGC
GGCGCCGCTCAGTCCGACAGAATATCATGCGCTGGCGCTCTGGTTGTATGCCCATCAGATGCGTCCGGGTGATCTGTTGC
TGCCAGACGGCGCCTCCGCTCTGCGAACATCGCCCGATGTACCGGTAAACCCGGAACGGTTGACGGCGCTGCTGGCACGT
GGCGGTGCGCTTGCGCTCTCAGTTGAAAAATGGGTCAACAAAGGGCTATGGGTGATGAGCAGGAGCGATGCAGATTATCC
ACAGCGCCTCAAGACACGCCTGGGACGCACTGCGCCGCCGCTGTTGTACGGCGCTGGAAATCGACAATTGCTCGGACAGG
GCGGGCTGGCGATTCTCGGCTCACGCAACAGTGCTGCGCACGCACTTGCCTTTACACGTCGGATTGCCGGTATGTGCGCA
CGTCAGGGTATGCCTGTTCTCTCCGGTGCAGCGCGCGGGGTTGATAGCGAGGCGATGCAGGCGGCGCTCGATGCGAGAGG
TGTTGTGATCGGCGTTCTGGCAGACAGTCTCTTGAAGGCAGCGGTTGGCAGGAACTATCGTCAGGCTGTGCGGAACGGCA
ATCTCGTCCTGGTATCAGCCTGTGATCCCGAAGCAGGTTTTACTGTCGGGAATGCGATGGGACGAAACAAGTATATCTAT
GCGTTGAGCGACTATGCGCTGGTGGTCAGTGCAGCGCTGGGTGAGGGTGGCGCGTGGAGCGGCGCTGTTGAAAATCTGAC
AAAACGCTGGGTTCCGCTGTTTGTCTGGATCGATGATGAATCGTTGCCAGGCAACCAACGTCTGCGCGATATGGGTGCGT
TGCCATTCAGTGAAAACCAATGTGCTGGCGAGTCAGTGCACGATCTTTTCAAACGCCTGGCAGATGAAACCACACCTCAA
CATGTGCTGTCAGGCAACGGCATGGTTGCATCTTCCAATGCTCGTGCGTCAGATGGCGGACATGCAGAAGAACAGACGGC
GTCCGCTGGCGATCAAACCAAAACCAATCTGTCGTCGGAACAGCAGGTGCTGGAATTGACAGCTGTCGAAGCCAACACCT
CCGCGCCGACCGTCGATCTATTTCCGATTGTCTGGCCATATCTGGAGCAGGCGCTGTATGCGGCGCAGACCGAGCGCGAA
CTGCTGTATGCGGCGCAGACCGAGCGCGAACTGGCGCAGCGCTGCGGCATTGAGCTAACGCAGGCGCGCGCCTGGCTGCA
ACGCGCCGTGCAGAAAGGATTGGTTGCGCGCCTGACCCGCCCAACGCGGTACGTCATCGCTTCCCCGATCACCCGCCACG
CCTGA

Structures

Antitoxin

• AlphaFold DB: A5UX61