Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1110879..1111499 Replicon chromosome
Accession NZ_CP085780
Organism Enterobacter hormaechei strain 48411CZ

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LJU35_RS05270 Protein ID WP_015571250.1
Coordinates 1110879..1111097 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LJU35_RS05275 Protein ID WP_006809850.1
Coordinates 1111125..1111499 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU35_RS05240 (LJU35_05240) 1106891..1107151 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LJU35_RS05245 (LJU35_05245) 1107154..1107294 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LJU35_RS05250 (LJU35_05250) 1107291..1108001 - 711 WP_047642343.1 GNAT family protein -
LJU35_RS05255 (LJU35_05255) 1108103..1109563 + 1461 WP_045349927.1 PLP-dependent aminotransferase family protein -
LJU35_RS05260 (LJU35_05260) 1109535..1110002 - 468 WP_023296041.1 YlaC family protein -
LJU35_RS05265 (LJU35_05265) 1110119..1110670 - 552 WP_015571251.1 maltose O-acetyltransferase -
LJU35_RS05270 (LJU35_05270) 1110879..1111097 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LJU35_RS05275 (LJU35_05275) 1111125..1111499 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LJU35_RS05280 (LJU35_05280) 1112010..1115156 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
LJU35_RS05285 (LJU35_05285) 1115179..1116372 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T221284 WP_015571250.1 NZ_CP085780:c1111097-1110879 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T221284 NZ_CP117370:c4802466-4802155 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT221284 WP_006809850.1 NZ_CP085780:c1111499-1111125 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT221284 NZ_CP117370:c4802154-4801864 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References