Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4423166..4423823 Replicon chromosome
Accession NZ_CP085774
Organism Enterobacter hormaechei strain 48947CZ

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LJU36_RS21405 Protein ID WP_017382887.1
Coordinates 4423166..4423576 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LJU36_RS21410 Protein ID WP_003863437.1
Coordinates 4423557..4423823 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU36_RS21385 (LJU36_21385) 4419164..4420897 - 1734 WP_023304383.1 single-stranded-DNA-specific exonuclease RecJ -
LJU36_RS21390 (LJU36_21390) 4420903..4421616 - 714 WP_023304384.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU36_RS21395 (LJU36_21395) 4421645..4422541 - 897 WP_023304385.1 site-specific tyrosine recombinase XerD -
LJU36_RS21400 (LJU36_21400) 4422643..4423164 + 522 WP_015571793.1 flavodoxin FldB -
LJU36_RS21405 (LJU36_21405) 4423166..4423576 - 411 WP_017382887.1 protein YgfX Toxin
LJU36_RS21410 (LJU36_21410) 4423557..4423823 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LJU36_RS21415 (LJU36_21415) 4424118..4425098 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LJU36_RS21420 (LJU36_21420) 4425210..4425869 - 660 WP_003863433.1 hemolysin III family protein -
LJU36_RS21425 (LJU36_21425) 4426136..4426867 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
LJU36_RS21430 (LJU36_21430) 4426984..4428417 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T221281 WP_017382887.1 NZ_CP085774:c4423576-4423166 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T221281 NZ_CP117370:c4137080-4136793 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT221281 WP_003863437.1 NZ_CP085774:c4423823-4423557 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT221281 NZ_CP117370:c4136806-4136504 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References